Differential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice.
10.9758/cpn.2016.14.3.279
- Author:
Jae Chun SONG
1
;
Mi Kyoung SEO
;
Sung Woo PARK
;
Jung Goo LEE
;
Young Hoon KIM
Author Information
1. Paik Institute for Clinical Research, Graduate School, Inje University, Busan, Korea. iybihwc@naver.com
- Publication Type:Original Article
- Keywords:
Olanzapine;
Haloperidol;
Memory;
NMDA antagonist;
Neurogenesis
- MeSH:
Animals;
Antipsychotic Agents;
Behavior Rating Scale;
Bromodeoxyuridine;
Cognition Disorders;
Dentate Gyrus;
Dizocilpine Maleate;
Haloperidol*;
Hippocampus;
Humans;
Immunohistochemistry;
Infant, Newborn;
Memory*;
Mice*;
Neurogenesis;
Spatial Memory;
Water
- From:Clinical Psychopharmacology and Neuroscience
2016;14(3):279-285
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. METHODS: MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to MK-801 for the final 4 days. Spatial memory performance was measured using a Morris water maze (MWM) test for 9 days (four trials/day). Immunohistochemistry with bromodeoxyuridine (BrdU) was used to identify newborn cells labeled in tissue sections from the dentate gyrus of the hippocampus. RESULTS: MK-801 administration over 9 days significantly impaired memory performance in the MWM test compared to untreated controls (p<0.05) and these deficits were blocked by treatment with olanzapine (p<0.05) but not haloperidol. The administration of MK-801 also resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus (28.6%; p<0.01), which was prevented by treatment with olanzapine (p<0.05) but not haloperidol. CONCLUSION: These results suggest that olanzapine has a protective effect against cognitive impairments induced by MK-801 in mice via the stimulating effects of neurogenesis.
