Application of metabolomics in nanotoxicity
10.3760/cma.j.cn121094-20190921-00312
- VernacularTitle:代谢组学在纳米毒理学研究中的应用
- Author:
Xiaoxue ZOU
1
;
Haijiao WANG
;
Lihua LIU
;
Bo ZHANG
Author Information
1. 102308 北京，国家卫生健康委职业安全卫生研究中心
- Keywords:
Metabolomics;
Nanoparticle;
Toxicology;
Metabolic pathway
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(9):712-717
- CountryChina
- Language:Chinese
-
Abstract:
As an emerging material with excellent property, nanoparticle has been widely used in multiple fields such as chemical industry, textile, biomedicine, etc., which has caused widespread concern about its potential toxicity in society. Due to the limitations of traditional toxicology technology, the high-throughput methods were urgently needed to assess the potential toxicity of particles at nanoparticle size systematically. Metabolomics has been recognized as an emerging omics technology developed by multidisciplinary combination of modern analytical techniques, biochemistry and bioinformatics, which has been widely used to screened early toxicity potential markers and metabolic pathway by analyzing changes in the types and quantities of metabolites in biological samples such as cells and tissues. This article reviewed the progress and challenges of metabolomics in nanotoxicology research.
