Imbalance between peripheral Th17 and regulatory T cells in children with allergic rhinitis and bronchial asthma
10.7619/jcmp.201713023
- VernacularTitle:儿童过敏性鼻炎和支气管哮喘中周围Th17和调节性T细胞的失衡
- Author:
Qinfang WU
1
;
Yu CHEN
;
Zhigang WANG
;
Wen SU
;
Chundi XU
Author Information
1. 上海市瑞金医院 儿科
- Keywords:
children;
allergic rhinitis;
bronchial asthma;
Th17;
Treg;
imbalance
- From:
Journal of Clinical Medicine in Practice
2017;21(13):88-91,99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the imbalance of peripheral Th17 cells(Th17)and regulatory T cells(Treg)in children with allergic rhinitis(AR)and bronchial asthma(BA)and its clinical significance.Methods A total of 25 children with simple AR(AR group),25 children with simple BA(BA group)and 25 children with AR complicated with BA(AR+BA group)were selected.Another 25 healthy children were selected as control group at the same time.The levels of Th17 cells and Treg cells in peripheral blood,immunoglobulin E(IgE),transforming growth factor β1(TGF-β1),percentage of forced expiratory volume in one second in predicted value(FEV1％)and levels of serum IL-6,IL-17,IL-23 and IL-10 were compared among four groups.The correlations between IgE,FEV1％and Th17,Treg,TGF-β1,IL-17 in children with AR complicated with BA were analyzed.Results There were significant differences in peripheral blood Th17 cells,Treg cells,IgE,TGF-β1 and FEV1％between AR group,BA group,AR+BA group and the control group(P<0.05).IL-17 level was significantly higher in AR+BA group than AR group and BA group(P<0.05).Correlation analysis showed that IgE was positively correlated with levels of Th17 and IL-17,and negatively correlated with Treg and TGF-β1(P<0.05).Conclusion There is imbalance of Th17 and Treg cells in children with AR and BA.Their expression are correlated with IgE and FEV1％.
