Analysis of quantitative changes of γδT cells in the peripheral blood of patients with chronic brucellosis
10.3760/cma.j.cn121094-20191008-00467
- VernacularTitle:γδT细胞在慢性布鲁氏菌病患者外周血中的数量变化分析
- Author:
Yamin LIU
1
;
Xiaoya ZHENG
;
Yuping WANG
;
Feinan LV
;
Qianqian REN
;
Bei JIANG
;
Ying LI
Author Information
1. 300192 天津市第二人民医院，天津市肝病医学研究所
- Keywords:
Brucellosis;
γδT cells;
CD4 +T lymphocytes;
CD8 +T lymphocytes;
CD3 + T lymphocytes
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(8):570-572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the quantitative changes of γδT cells in peripheral blood before and after anti-Brucella treatment in patients with chronic brucellosis.Methods:A prospective design was used to 88 patients with chronic brucellosis who were admitted to the Second People's Hospital of Tianjin from September 2012 to April 2018. The patients took anti-brucella drugs, And the changes in the number of γδT cell, CD3 +, CD4 +, CD8 +T lymphocytes and CD4/8 in peripheral blood before treatment, 6 weeks and 12 weeks after treatment were analyzed. Thirty volunteers were selected as the healthy control group from Tianjin Second People's Hospital employee health checkup in 2014. Results:After 6 weeks antibacterial therapy, the counts of CD3 +, CD4 + and CD8 +T lymphocytes were significantly lower than before treatment in patients with chronic brucellosis ( P<0.05) . After 12 weeks antibacterial therapy, the counts of γδT cell, CD3 +, CD4 + and CD8 +T lymphocytes were significantly lower than before treatment ( P<0.05) , but CD4/8 was higher than before treatment in patients with chronic brucellosis ( P<0.05) . Compared with healthy control group, after 6 weeks antibacterial treatment, the γδT cell count was still significantly higher, but the CD4 +T lymphocyte count was lower ( P<0.05) . After 12 weeks treatment, the γδT cell count was still significantly higher than that of the healthy control group ( P<0.01) . Conclusion:γδ T cells, CD4 +, CD8 + and CD3 +T lymphocytes may play a role in human body resistance to chronic Brucella infection.
