Downregulation of miR-503 Promotes ESCC Cell Proliferation, Migration, and Invasion by Targeting Cyclin D1
- Author:
Jiang LANFANG
1
;
Zhao ZITONG
;
Zheng LEILEI
;
Xue LIYAN
;
Zhan QIMIN
;
Song YONGMEI
Author Information
1. State Key Laboratory of Molecular Oncology
- Keywords:
Esophageal squamous cell carcinoma;
miR-503;
Cyclin D1;
Proliferation;
Migration and invasion
- From:
Genomics, Proteomics & Bioinformatics
2017;15(3):208-217
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers in China, but the underlying molecular mechanism of ESCC is still unclear. Involvement of micro-RNAs has been demonstrated in cancer initiation and progression. Despite the reported function of miR-503 in several human cancers, its detailed anti-oncogenic role and clinical significance in ESCC remain undefined. In this study, we examined miR-503 expression by qPCR and found the downregulation of miR-503 expression in ESCC tissue relative to adjacent normal tissues. Fur-ther investigation in the effect of miR-503 on ESCC cell proliferation, migration, and invasion showed that enhanced expression of miR-503 inhibited ESCC aggressive phenotype and overexpres-sion of CCND1 reversed the effect of miR-503-mediated ESCC cell aggressive phenotype. Our study further identified CCND1 as the target gene of miR-503. Thus, miR-503 functions as a tumor suppressor and has an important role in ESCC by targeting CCND1.
