Vitamin Pharmacogenomics: New Insight into Individual Differences in Diseases and Drug Responses
- Author:
He HAI-YAN
1
Author Information
1. International Medical Department
- Keywords:
Vitamin;
Pharmacogenomics;
Single nucleotide polymor-phism;
Genetic variation;
Individual difference
- From:
Genomics, Proteomics & Bioinformatics
2017;15(2):94-100
- CountryChina
- Language:Chinese
-
Abstract:
Vitamins are vital to sustain normal physiological function, metabolism, and growth for all living organisms. Being an integral component of coenzyme, vitamins can affect the catalytic activities of many enzymes and the expression of drug transporters. Genetic variations in metabo-lism and/or transporter genes of drugs can influence the exposure of the human body to drugs and/or their active metabolites, thus contributing to the variations in drug responses and toxicities. Nonetheless, pharmacogenomics studies on nutrients have been rarely summarized. In this article, we reviewed recent progress on vitamin pharmacogenomics, for a better understanding on the influ-ence of vitamin-related gene polymorphisms on inter-individual differences in diseases and drug efficacy and safety.
