A 5-year follow-up study of pneumoconiosis patients with positive autoantibody
10.3760/cma.j.cn121094-20190927-00419
- VernacularTitle:自身抗体阳性的尘肺病患者五年随访研究
- Author:
Wenzhong JIANG
1
;
Tingting ZHANG
;
Yuquan CHEN
;
Zhaohuan LUO
;
Jingru LIN
;
Haixia WANG
;
Yimin LIU
Author Information
1. 510620 广州市第十二人民医院
- Keywords:
Pneumoconiosis;
Autoantibodies;
Small shadow;
Lung function;
Follow-up studies
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(6):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the progress of small shadow and the change of lung function in pneumoconiosis with positive autoantibody, so as to provide basis for clinical treatment of pneumoconiosis.Methods:A total of 756 patients were admitted to the pneumoconiosis department of the Guangzhou Occupational Disease Prevention Hospital from January 1, 2013 to June 1, 2019. The patients with combined infection were excluded. According to whether the autoantibody was positive, they were divided into positive group and negative group, 25 cases in each group. Follow-up observation of X-ray chest radiographs, chest CT, forced expiratory volume in one second (FEV 1) and forced expired flow at 50% of FVC (MEF 50) of pneumoconiosis patients for 5 years, to analyze the influence of positive autoantibody on the morphology of X-ray chest film, the pneumoconiosis promotion in 5 years and lung function. Results:There were 22 males and 3 females in the autoantibody positive group, aged 53.14±10.51 years. In the autoantibody negative group, there were 23 males and 2 females, aged 53.88±8.10 years. During the 5-year observation period, there was no significant difference of small shadow shape, pneumoconiosis stage, and the pneumoconiosis promotion in 5 years between the autoantibody positive group and the autoantibody negative group ( P>0.05). However, the increment of small shadow area in the autoantibody positive group was higher than that in the autoantibody negative group ( P<0.05). FEV 1 and MEF 50 of the autoantibody positive group were significantly lower than those of the autoantibody negative group in the fourth and third years, respectively ( P<0.05). Positive autoantibody was negatively correlated with FEV 1 and MEF 50 ( P<0.05). Conclusion:The positive autoantibody can't promote the progress of X-ray, but show more small shadows on chest CT; the positive autoantibody may aggravate the decline of lung function.
