Increased Neutrophil/Lymphocyte Ratio in Patients with Depression is Correlated with the Severity of Depression and Cardiovascular Risk Factors.
- Author:
Esra AYDIN SUNBUL
1
;
Murat SUNBUL
;
Omer YANARTAS
;
Fatma CENGIZ
;
Mehmet BOZBAY
;
Ibrahim SARI
;
Huseyin GULEC
Author Information
- Publication Type:Original Article
- Keywords: Depression; Lymphocyte; Neutrophil; Inflammatory; Cardiovascular risk
- MeSH: Depression*; Depressive Disorder; Humans; Inflammation; Leukocyte Count; Logistic Models; Lymphocytes; Neutrophils; Risk Factors*; Sensitivity and Specificity
- From:Psychiatry Investigation 2016;13(1):121-126
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Chronic inflammation is associated with cardiovascular (CV) risk factors and psychiatric disorders. The neutrophil to lymphocyte ratio (NLR) has been investigated as a new biomarker for systemic inflammatory response. The aim of the study is to investigate the relation of NLR with severity of depression and CV risk factors. METHODS: The study population consisted of 256 patients with depressive disorder. Patients were evaluated with the Hamilton Rating Scale for Depression (HAM-D). Patients were classified into four groups according to their HAM-D score such as mild, moderate, severe, and very severe depression. Patients were also evaluated in terms of CV risk factors. RESULTS: Patients with higher HAM-D score had significantly higher NLR levels compared to patients with lower HAM-D score. Correlation analysis revealed that severity of depression was associated with NLR in depressive patients (r=0.333, p<0.001). Patients with one or more CV risk factors have significantly higher NLR levels. Correlation analysis revealed that CV risk factors were associated with NLR in depressive patients (r=0.132, p=0.034). In logistic regression analyses, NLR levels were an independent predictor of severe or very severe depression (odds ratio: 3.02, 95% confidence interval: 1.867-4.884, p<0.001). A NLR of 1.57 or higher predicted severe or very severe depression with a sensitivity of 61.4% and specificity of 61.2%. CONCLUSION: Higher HAM-D scores are associated with higher NLR levels in depressive patients. NLR more than 1.57 was an independent predictor of severe or very severe depression. A simple, cheap white blood cell count may give an idea about the severity of depression.
