Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
- Author:
Fang YIWEN
1
;
Fullwood J MELISSA
Author Information
1. Cancer Science Institute of Singapore
- Keywords:
lncRNAs;
Chromatin;
Transcription regulation;
Antisense oligonucleotides;
Cancer
- From:
Genomics, Proteomics & Bioinformatics
2016;(1):42-54
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a vari-ety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can func-tion as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identi-fying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.
