Progress in study on intervention of silica-induced pulmonary fibrosis with the exosomes released from mesenchymal stem cells
10.3760/cma.j.cn121094-20190709-00275
- VernacularTitle:间充质干细胞源外泌体干预矽肺纤维化的研究进展
- Author:
Xiaodong SHI
1
;
Lijia YU
;
Yansong ZHANG
Author Information
1. 102308 北京，国家卫生健康委职业安全卫生研究中心
- Keywords:
Silicosis;
Pulmonary fibrosis;
Mesenchymal stem cells;
Exosomes
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2020;38(4):309-313
- CountryChina
- Language:Chinese
-
Abstract:
Pneumoconiosis is an occupational disease which seriously endangers the health of workers exposed to dust. Silica is regarded as the most serious cause of pneumoconiosis because it can cause diffuse pulmonary fibrosis in workers' lung tissue. Mesenchymal stem cells (MSCs) are adult stem cells with multiple differentiation potential. As member of extracellular vesicles family, exosomes can be secreted from MSCs to regulate and intervene tumorigenesis, cardiovascular disease, immune system disorder and tissue damage disease. This article reviews the experimental results in the field of intervention of MSCs and its exosomes in silicosis research in recent years, which plays an important role in indicating direction in the future research on the mechanism and function of MSCs exosomes in the therapy of silica-induced pulmonary fibrosis.
