Changes of adiponectin and retinol-binding protein 4 in patients with obstructive sleep apnea-hypopnea syndrome and type 2 diabetes mellitus and their clinical significance
10.7619/jcmp.201711010
- VernacularTitle:2型糖尿病合并阻塞性睡眠呼吸暂停低通气综合征患者血清脂联素和视黄醇结合蛋白4水平变化及临床意义
- Author:
Huan YANG
1
;
Min SHI
;
Huixing DONG
;
Yongde PENG
Author Information
1. 上海交通大学附属第一人民医院 内分泌科
- Keywords:
obstructive sleep apnea-hypopnea syndrome;
apnea-hypopnea index;
type 2 diabetes mellitus;
adiponectin;
retinol-binding protein 4
- From:
Journal of Clinical Medicine in Practice
2017;21(11):31-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the levels of serum adiponectin (ADPN) and retinol-binding protein 4 (RBP4) in patients with type 2 diabetes mellitus (T2DM) and obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods A total of 155 patients with T2DM and OSAHS were selected and divided into mild group (n=62),moderate group (n=53) and severe group (n=40) according to apnea-hypopnea index (AHI),35 OSAHS patients were designed as OSAHS group,42 T2DM patients were selected as T2DM group,and 38 healthy controls were selected as control group.Serum ADPN and RBP4 levels were detected by ELISA.Results Compared with healthy controls,the serum level of RBP4 significantly increased and the ADPN level significantly decreased in the other three groups (P<0.01).In subgroups of OSAHS and T2DM group,the level of RBP4 increased with increasing of AHI level,ADPN level is on the contrary (P<0.01).Conclusion The serum levels of ADPN and RBP4 are closely related with the severity of T2DM patients with OSAHS.
