Nanopore-based Fourth-generation DNA Sequencing Technology
- Author:
Feng YANXIAO
1
;
Zhang YUECHUAN
;
Ying CUIFENG
;
Wang DEQIANG
;
Du CHUNLEI
Author Information
1. Chongqing Key Laboratory of Multi-scale Manufacturing Technology
- Keywords:
Nanopore;
DNA sequencing;
Single base;
Single molecule
- From:
Genomics, Proteomics & Bioinformatics
2015;(1):4-16
- CountryChina
- Language:Chinese
-
Abstract:
Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than$100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications.
