Pathway-based Analysis Tools for Complex Diseases:A Review
10.1016/j.gpb.2014.10.002
- Author:
Jin LV
1
;
Zuo XIAO-YU
;
Su WEI-YANG
;
Zhao XIAO-LEI
;
Yuan MAN-QIONG
;
Han LI-ZHEN
;
Zhao XIANG
;
Chen YE-DA
;
Rao SHAO-QI
Author Information
1. Institute for Medical Systems Biology
- Keywords:
Complex disease;
Pathway-based analysis;
Algorithms;
Software and databases
- From:
Genomics, Proteomics & Bioinformatics
2014;(5):210-220
- CountryChina
- Language:Chinese
-
Abstract:
Genetic studies are traditionally based on single-gene analysis. The use of these analyses can pose tremendous challenges for elucidating complicated genetic interplays involved in complex human diseases. Modern pathway-based analysis provides a technique, which allows a comprehen-sive understanding of the molecular mechanisms underlying complex diseases. Extensive studies uti-lizing the methods and applications for pathway-based analysis have significantly advanced our capacity to explore large-scale omics data, which has rapidly accumulated in biomedical fields. This article is a comprehensive review of the pathway-based analysis methods––the powerful methods with the potential to uncover the biological depths of the complex diseases. The general concepts and procedures for the pathway-based analysis methods are introduced and then, a comprehensive review of the major approaches for this analysis is presented. In addition, a list of available path-way-based analysis software and databases is provided. Finally, future directions and challenges for the methodological development and applications of pathway-based analysis techniques are dis-cussed. This review will provide a useful guide to dissect complex diseases.
