Efficacy of endoscopic submucosal dissection in the treatment of early gastric canceRand high-grade intraepithelial neoplasia
10.7619/jcmp.201709014
- VernacularTitle:内镜黏膜下剥离术治疗早期胃癌及高级别上皮内瘤变的疗效分析
- Author:
Haihan ZHANG
1
;
Jianxia JIANG
Author Information
1. 南京医科大学第一附属医院 消化内科
- Keywords:
early gastric cancer;
high-grade intraepithelial neoplasia of gastric mucosa;
endoscopic submucosal dissection;
curative resection;
follow up
- From:
Journal of Clinical Medicine in Practice
2017;21(9):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate value of endoscopic submucosal dissection foRearly gastric canceR(EGC) and high-grade intraepithelial neoplasia (HGIN) using endoscopic submucosal dissection (ESD) and its risk factors influencing dissection.Methods The date of 80 patients who underwent ESD foREGC and HGIN in ouRhospital from DecembeR2012 to June 2014 were retrospectively reviewed.The clinical manifestation,endoscopic appearance and histopathological information were collected and the risk factors influencing curative resection afteRESD were analyzed.Results Among the enrolled 80 patients,the overall resection rate was 100%,the complete resection rate was 86.25% and the curative resection rate was 86.25%.The curative resection rate of the EGC group was significantly less than that of the HGIN group,(93.6% vs.75.76%,P<0.05).Single factoRanalysis revealed that patients with the following criteria were more likely to have higheRresection rate:a lesion size ≥2 cm,submucosa invasion and ulceration (P<0.05).Additional multivariate regression analysis demonstrated that submucosa invasion (OR=6.300,95% CI: 0.516-12.658,P<0.001),a lesion size ≥2 cm(OR=12.193,95% CI: 1.323～112.347,P=0.027) and ulceration(OR=5.679,95% CI: 1.087～29.678,P=0.040)were independent risk factors foRresection.Conclusion ESD is effective method foREGC and HGIN patients.Strictly evaluation and comprehensive treatment method are necessary foRsubmucosa invasion,lesion size ≥2 cm,and ulceration patients.
