Polymorphism in the IL-1 Receptor Antagonist Gene in Vitiligo.
10.5021/ad.1995.7.4.299
- Author:
Yong Suk LEE
;
Kyong Chan PARK
;
Sang Woong YOUN
;
Hyeong Don BANG
;
Kyu Han KIM
- Publication Type:Original Article
- Keywords:
IL-1 receptor antagonist;
IL-1 receptor antagonist gene;
Polymorphism;
Vitiligo
- MeSH:
Alleles;
Humans;
Interleukin-1*;
Vitiligo*
- From:Annals of Dermatology
1995;7(4):299-302
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The severity of several chronic inflammatory diseases was reported to be associated with polymorphism of the IL-1 receptor antagonist gene(IL-lrn). OBJECTIVE: This study was performed to study the polymorphism of the IL-1rn in vitiligo and in the normal Korean population. METHODS: Thirty one cases of vitiligo and seventy nine normal Koreans as control were studied for the polymorphism of IL-1 rn. RESULTS: The frequency of allele 2 of the IL- I rn in 31 patients with vitiligo was compared with that of the 79 healthy controls. The frequency of allele 2 was 1.6% in vitiligo patients and 3.8% in the normal controls. CONCLUSION: There was no significant difference in the frequency of allele 2 between the vitiligo patients and normal controls.
