Characteristics of lung function in patients with asbestosis of different stages
10.3760/cma.j.issn.1001-9391.2016.09.013
- VernacularTitle:不同期别石棉肺患者的肺功能差异
- Author:
Xiaoli YANG
1
,
2
;
Xiaoli ZHU
;
An LI
;
Xuqin DU
;
Yuguo SONG
;
Qiao YE
Author Information
1. 100020北京,首都医科大学附属北京朝阳医院,职业病与中毒医学科
2. 北京京煤集团总医院尘肺与结核病科
- Keywords:
Asbestosis;
Respiratory function tests;
Radiography
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2016;34(9):687-690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of lung function in the patients with asbestosis of different stages,and analyze the correlations between the puhnonary function values and imaging score of chest X-ray.Methods A cohort of newly diagnosed 249 asbestosis patients over a period of eight years in a single center were evaluated.Clinical data were colleeted from clinical charts.Radiographs were reviewed by the experts blinded to clinical data.The asbestosis patieuts were classified into Ⅰ to Ⅲ stages by chest X-ray according to the guideline.The correlations between the pulmonary function values and imaging score of chest Xray were aualyzed.Results The prevalence of stage Ⅰ to Ⅲ in this asbestosis cohort was 73.5％,19.3％ and 7.2％ respectively.With the stages iucreasing,the patients' forced vital capacity (FVC),total lung capacity (TLC),total carbon nonoxide diflitsion capacity (DLCO) predicted values were all reduced showing the restrictive ventilation impairment and/or gas exchange barrier.The obstruction of the small respiratory tracts was detected in the asbestosis of all the different stages.According to the small shadow density of each lung area,chest small shadow density score had a siguifieant negative correlation with FVC,TLC or DLCO predicted values respectively (all P＜O.01).Conclusion The patients with asbestosis of different stages had varying degrees of gas exchange impairment,small airway dysfunction with or without ventilation dysfunction.The decreasing of DLCO was earlier than lung volume change.Chest X-ray image score paralleled the decline of lung function values,reflecting the severity of the disease.
