Effects of chronic exposure to monochloroacetic acid on the lung function and lymphocyte subsets in occupational exposed workers
10.3760/cma.j.issn.1001-9391.2016.09.008
- VernacularTitle:慢性氯乙酸接触对作业工人肺功能及淋巴细胞亚群的影响
- Author:
Tao MENG
1
;
Qing JIA
;
Panpan MIAO
;
Meili SHEN
;
Yong NIU
;
Yufei DAI
Author Information
1. 中国疾病预防控制中心职业卫生与中毒控制所化学污染物与健康安全重点实验室
- Keywords:
Monochloroacetic acid;
Occupational exposure;
Epidemiologic studies;
Lymphocyte subsets;
Respiratory function tests
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2016;34(9):669-673
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of chronic exposure to monochloroacetic acid on the lung function and whole blood counts in occupational exposed workers,and provide new markers for occupational health surveillance.Methods We conducted a cross-sectional molecular epidemiology study of 121 workers who were occupationally exposed to monochloroacetic acid and 69 unexposed workers frequencymatched by age and smoking status from the same geographic region.The lung function was measured by portable lung function instrument,and the lymphocyte subsets were measured by flow eytometry.Linear regression was used to test for differences in the levels of each marker between exposed and control workers.Results FEV1.0/FVC was significantly decreased in both male and female workers exposed to monochloroacetic acid compared to unexposed workers (P＜0.01) after adjusting for potential confounders,which were highly consisteut when stratified by smoking status.Among male workers,monochloroacetic acid exposure was associated with significant decrease in the levels of CD8+ T cells (P＜0.05) and monocytes (P＜0.05),and these statistically significant differences were observed between exposure and control workers only among smokers,not among non-smokers.However,there were no significant differences in the levels of whule blood cells and lymphocyte subsets between two groups anong female workers.Conclusion The chronic monochloroacetic acid exposure was associated with pulmonary dysfunction and immunosuppression,which mainly occurred among nale workers and smokers.
