The Effect of Calcitonin Gene-Related Peptide on Hair Growth in Vitro.
10.5021/ad.1995.7.4.308
- Author:
Dae Hun SUH
;
Hee Chul EUN
- Publication Type:Original Article
- Keywords:
Calcitonin gene-related peptide(CGRP);
Growth;
Hair follicle
- MeSH:
Calcitonin Gene-Related Peptide*;
Calcitonin*;
Hair Follicle;
Hair*;
In Vitro Techniques*;
Keratinocytes;
Nerve Fibers;
Skin;
Thymidine
- From:Annals of Dermatology
1995;7(4):308-312
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Calcitonin gene-related peptide(CGRP)-containing nerve fibers are widely distributed in the skin including the area around hair follicles. OBJECTIVE: This study was undertaken to investigate the effect of CGRP on normal hair growth in vitro. METHODS: CGRP was added to isolated anagen hair follicles in Williams' E media or keratinocyte growth media(KGM). Measuring the length of hair follicles and thymidine uptake were used for hair growth parameters. RESULTS: CGRP-treated groups generally showed no significant difference of hair follicle length and thymidine uptake in both media compared to the controls. However, hair follicle length was significantly increased at a high concentration of CGRP in KGM compared to the controls. CONCLUSION: Our study suggested that CGRP may be a promoter of hair follicle growth in vitro.
