The immunological effects of phthalanilic acid on mice
10.3760/cma.j.issn.1001-9391.2016.05.012
- VernacularTitle:苯肽胺酸对小鼠的免疫毒性作用
- Author:
Lingling DAI
1
;
Sihua WEI
;
Wan ZHUANG
;
Long LI
Author Information
1. 430030 武汉,华中科技大学同济医学院公共卫生学院卫生毒理学系,教育部环境与健康重点实验室
- Keywords:
Phthalanilic acid;
Mice;
Interferon type Ⅱ;
Interleukin-4
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2016;34(5):363-366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of phthalanilic acid on immune system in mice from the respects of blood,tissues,cell and cytokines.And to find sensitive index of immunological effects and offer experimental data for toxicological safety evaluation.Methods 60 balb/c mice were randomly divided into 4 groups.The mice in control group were given soybean oil.The mice in group 2 to 4 were given phthalanilic acid at dose 30 mg/kg,100 mg/kg and 300 mg/kg by gavage respectively for 28 days.After 24 hours of the last contamination,the histopathology of spleen and thymus,immunologic factors and cell multiplication of lymphocyte were analysed.The data were analysed by SPSS.Results After contamination for 28 days,300 mg/kgphthalanilic acid could cause that the cell multiplication of lymphocyte were inhibited.Spleens were damaged at the dose of 100 mg/kg.The concentration of IFN-γand IL-4[(843.31 ±14.81) pg/ml and (1174.44t7.32) pg/ml]in thymus were increased significantly (P＜0.05) at the dose of 30 mg/kg.Conclusion Different doses of phthalanilic acid may damnify the immune system of mice at different degrees for 28 days continuous contamination.Phthalanilic acid might have immunotoxicity.
