A Brief Review on the Mechanisms of miRNA Regulation
10.1016/S1672-0229(08)60044-3
- Author:
Cai YIMEI
1
;
Yu XIAOMIN
;
Hu SONGNIAN
;
Yu JUN
Author Information
1. Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences,Beijing 100029,China
- Keywords:
non-coding RNA;
miRNA;
miRNA regulation;
targets
- From:
Genomics, Proteomics & Bioinformatics
2009;7(4):147-154
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are a class of short,endogenously-initiated non-coding RNAs that post-transcriptionally control gene expression via either translational repression or mRNA degradation.It is becoming evident that miRNAs are play-ing significant roles in regulatory mechanisms operating in various organisms,including developmental timing and host-pathogen interactions as well as cell differentiation,proliferation,apoptosis and tumorigenesis.Likewise,as a regu-latory element,miRNA itself is coordinatively modulated by multifarious effectors when carrying out basic functions,such as SNP,miRNA editing,methylation and circadian clock.This mini-review summarized the current understanding of in-teractions between miRNAs and their targets,including recent advancements in deciphering the regulatory mechanisms that control the biogenesis and functional-ity of miRNAs in various cellular processes.
