Effects of malathion on testicular enzyme activities and sperm quality of male rats
10.3760/cma.j.issn.1001-9391.2016.05.003
- VernacularTitle:马拉硫磷对大鼠睾丸标志酶活力和精子质量的影响
- Author:
Xiao GENG
1
;
Cunxiang BO
;
Hua SHAO
Author Information
1. 山东省职业卫生与职业病防治研究院
- Keywords:
Malathion;
Rats;
Testis;
Acid phosphatase;
Lactate dehydrogenase
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2016;34(5):329-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study is to investigate the effects of sub chronic exposure to malathion on testicular enzyme activities and sperm quality of male rats.Methods Forty male rats were divided into four groups:three exposure groups and a control group.Malathion was administered orally to male rats at 0,33.75,54.00,and 108.00 mg/kg for 60 days to evaluate the toxic alterations in sperm dynamics and testicular enzyme activities including ACP,LDH,SDH and γ-GT.The control rats were administered with an equivalent volume of distilled water in the same manner.After sacrificed,the testes were collected and weighed.Results The body weight and the testis weight of animals showed a decreasing tendency,and there was a statistical difference between the 54.00,108.00 mg/kg groups,and the control group (P＜0.05).Malathion brought about marked reduction in testicular sperm counts,sperm motility,and significant growth of sperm malformation rate in 108.00 mg/kg group.A significant decrease in the activities of testicular enzyme ACP and γ-GT was observed in malathion exposed rats,while the activities of LDH was significant increased and there were no obvious effects on the activities of SDH.The activities of ACP,γ-GT and LDH showed a statistical difference between the 108.00 mg/kg groups,and the control group.Conclusion Malathion reduced the sperm counts and sperm motility,increased the malformation rate and reduced the activities of testicular enzymies of male rats.
