Chromosome aberration and micronucleus frequency in peripheral blood lymphocytes in radiation workers
10.3760/cma.j.issn.1001-9391.2016.04.009
- VernacularTitle:放射工作人员外周血淋巴细胞染色体畸变和微核率分析
- Author:
Qihong ZHOU
1
;
Huijuan YU
;
Fengyun FU
;
Haipeng YE
Author Information
1. 310014,杭州市职业病防治院检验科
- Keywords:
Chromosome;
Micronuclei;
Radiation,ionizing;
Radiation work
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2016;34(4):275-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate chromosome aberration and micronucleus frequency in peripheral blood lymphocytes in workers engaged in radiation for a long time,to reduce occupational hazard caused by ionizing radiation,and to further strengthen health surveillance.Methods A total of 366 members of medical staff engaged in radiation work who underwent physical examinations in Hangzhou Hospital of Prevention and Treatment of Occupation Diseases from 2014 to 2015 were enrolled as radiation group,consisting of staff engaged in X-ray diagnosis,diagnostic radiology,radiotherapy,and interventional radiology.Another 100 members of medical staff without exposure to radiation were enrolled as control group.Whole blood culture was used to measure chromosome aberration and micronucleus frequency in peripheral blood lymphocytes.Results The radiation group had a significantly higher rate of chromosome aberration than the control group(0.30％ vs 0.09％,x2=13.43,P＜0.01),as well as a significantly higher micronucleus frequency than the control group (2.09‰ vs 0.08‰,x2=74.4,P＜0.01).The abnormal rates of chromosome aberration and micronucleus showed no significant differences across radiation workers with different working years (P＞0.05).The staff engaged in X-ray diagnosis,diagnostic radiology,radiotherapy,and interventional radiology had rates of chromosome aberration of 0.25％,0.25％,0.23％,and 0.41％,respectively,which showed a significant difference between the staff at these four posts (x2=8.22,P＜0.05);the micronucleus frequencies in the staff at these four posts were 1.36‰,1.28‰,1.14‰,and 3.79‰,respectively,and showed a significant difference between the staff at these four posts (x2=251.09,P＜0.01).Conclusion Radiation workers are exposed to low-dose ionizing radiation for a long time,which may cause significant increases in the rate of chromosome aberration and micronucleus frequency in peripheral blood lymphocytes.
