Mycobacterial PE_PGRS Proteins Contain Calcium-Binding Motifs with Parallel β-roll Folds
- Author:
Bachhawat NANDITA
1
;
Singh BALVINDER
Author Information
1. Department of Bioinformatics, DAV College, Chandigarh 160012, India
- Keywords:
Mycobacterium tuberculosis;
virulence factors;
PE_PGRS;
calcium-binding motif;
parallelβ-roll fold
- From:
Genomics, Proteomics & Bioinformatics
2007;2(3):236-241
- CountryChina
- Language:Chinese
-
Abstract:
The PE_PGRS family of proteins unique to mycobacteria is demonstrated to con- rain multiple calcium-binding and glycine-rich sequence motifs GGXGXD/NXUX. This sequence repeat constitutes a calcium-binding parallel/3-roll or parallel β-helix structure and is found in RTX toxins secreted by many Gram-negative bacteria. It is predicted that the highly homologous PE_PGRS proteins containing multiple copies of the nona-peptide motif could fold into similar calcium-binding structures. The implication of the predicted calcium-binding property of PE_PGRS proteins in the Ught of macrophage-pathogen interaction and pathogenesis is presented.
