A Network Partition Algorithm for Mining Gene Functional Modules of Colon Cancer from DNA Microarray Data
- Author:
Ruan XIAO-GANG
1
;
Wang JIN-LIAN
;
Li JIAN-GENG
Author Information
1. 北京理工大学
- Keywords:
DNA microarray data;
colon cancer;
gene functional module;
GN algorithm
- From:
Genomics, Proteomics & Bioinformatics
2006;4(4):245-252
- CountryChina
- Language:Chinese
-
Abstract:
Computational analysis is essential for transforming the masses of microarray data into a mechanistic understanding of cancer. Here we present a method for finding gene functional modules of cancer from microarray data and have applied it to colon cancer. First, a colon cancer gene network and a normal colon tissue gene network were constructed using correlations between the genes. Then the modules that tended to have a homogeneous functional composition were identified by splitting up the network. Analysis of both networks revealed that they are scale-free.Comparison of the gene functional modules for colon cancer and normal tissues showed that the modules' functions changed with their structures.
