Correlation between polymorphisms of RAD50, IL-33 and IL1 RL1 and allergic asthma in Han population

VernacularTitle:RAD50,IL-33和IL1RL1基因与汉族人群过敏性哮喘发病的相关性
Author: Jiebin CHEN ¹ ; Jie ZHANG ; Haozhong HU ; Yingji JIN ; Mei XUE
Author Information

1. 江苏省泰州市人民医院儿科
Keywords: asthma; genetic polymorphism; Chinese population
From: Journal of Clinical Medicine in Practice 2017;21(5):97-101
CountryChina
Language:Chinese
Abstract: Objective To investigate correlation between genetic polymorphisms of CDHR3 (rs6967330),GSDMB (rs2305480),IL-33 (rs928413),RAD50 (rs6871536) and IL1RL1 (rs1558641) and occurrence and severity of allergic asthma in Han population.Methods Genotype and allele frequencies were compared between 516 patients and 552 controls by Chi-square test.Correlation between genotype and FEV1,total IgE was analyzed.Results Compared with the controls,the allergic patients had significantly higher allergic G of rs928413 and allergic C of rs6871536 (P ＜0.001).Besides,allergic patients were found to have significantly lower frequency of allergic A of rs1558641 (P =0.007).Compared with other genotypes,patients with rs928413 genotype GG and rs1558641 genotype GG were significantly correlated with low FEV1％ and high level of serum total IgE.Conclusion Gene IL-33,IL1R1,and RAD50 are correlated with the risk of asthma in Han population.