Glia Maturation Factor Gamma (GMFG): A Cytokine-Responsive Protein During Hematopoietic Lineage Development and Its Functional Genomics Analysis
- Author:
Shi YING
1
;
Chen LING
;
A.Liotta LANCE
;
Wan HONG-HUI
;
P.Rodgers GRIFFIN
Author Information
1. National Institutes of Health (NIH)
- Keywords:
GMFG;
hematopoiesis;
proteomics;
functional genomics
- From:
Genomics, Proteomics & Bioinformatics
2006;4(3):145-155
- CountryChina
- Language:Chinese
-
Abstract:
Human hematopoiesis was evaluated using the techniques of controlled stem cell differentiation, two-dimensional gel electrophoresis-based proteomics, and functional genomics. We provide the first report that glia maturation factor gamma (GMFG) is a cytokine-responsive protein in erythropoietin-induced and granulocyte-colony stimulating factor-induced hematopoietic lineage development.Results from global functional genomics analysis indicate that GMFG possesses several other features: hematopoietic tissue-specific gene expression, a promoter concentrated with high-score hematopoiesis-specific transcription factors, and possible molecular coevolution with a rudimentary blood/immune system. On the basis of our findings, we hypothesize that GMFG is a hematopoietic-specific protein that may mediate the pluripotentiality and lineage commitment of human hematopoietic stem cells.
