Characterizing the Microenvironment Surrounding Phosphorylated Protein Sites
- Author:
Fan SHI-CAI
1
;
Zhang XUE-GONG
Author Information
1. 清华大学
- Keywords:
protein phosphorylation;
microenvironment;
modified shell model;
rank-sum test
- From:
Genomics, Proteomics & Bioinformatics
2005;3(4):213-217
- CountryChina
- Language:Chinese
-
Abstract:
Protein phosphorylation plays an important role in various cellular processes. Due to its high complexity, the mechanism needs to be further studied. In the last few years, many methods have been contributed to this field, but almost all of them investigated the mechanism based on protein sequences around protein sites. In this study, we implement an exploration by characterizing the microenvironment surrounding phosphorylated protein sites with a modified shell model, and obtain some significant properties by the rank-sum test, such as the lack of some classes of residues, atoms, and secondary structures. Furthermore, we find that the depletion of some properties affects protein phosphorylation remarkably. Our results suggest that it is a meaningful direction to explore the mechanism of protein phosphorylation from microenvironment and we expect further findings along with the increasing size of phosphorylation and protein structure data.
