Classifying Genomic Sequences by Sequence Feature Analysis
- Author:
Liu ZHI-HUA
1
;
Jiao DIAN
;
Sun XIAO
Author Information
1. 东南大学
- Keywords:
genome;
sequence feature analysis;
BBC;
PCA;
discriminant analysis
- From:
Genomics, Proteomics & Bioinformatics
2005;3(4):201-205
- CountryChina
- Language:Chinese
-
Abstract:
Traditional sequence analysis depends on sequence alignment. In this study, we analyzed various functional regions of the human genome based on sequence features, including word frequency, dinucleotide relative abundance, and base-base correlation. We analyzed the human chromosome 22 and classified the upstream,exon, intron, downstream, and intergenic regions by principal component analysis and discriminant analysis of these features. The results show that we could classify the functional regions of genome based on sequence feature and discriminant analysis.
