The Evolutionary Relationship of the Domain Architectures in the RhoGEF-containing Proteins
- Author:
Sun QING-LAN
1
;
Zhou HONG-JUN
;
Lin KUI
Author Information
1. 北京师范大学
- Keywords:
protein domain;
domain architecture;
phylogenetic analysis;
domain loss;
RhoGEF-containing proteins
- From:
Genomics, Proteomics & Bioinformatics
2005;3(2):94-106
- CountryChina
- Language:Chinese
-
Abstract:
Domain insertions and deletions lead to variations in the domain architectures of the proteins from their common ancestor. In this work, we investigated four groups of the RhoGEF-containing proteins from different organisms with domain architectures RhoGEF-PH-SH3, SH3-RhoGEF-PH, RhoGEF-PH, and SH3-RhoGEF defined in the Pfam database. The phylogenetic trees were constructed using each individual domain and/or the combinations of all the domains. The phylogenetic analysis suggests that RhoGEF-PH-SH3 and SH3-RhoGEF-PH might have evolved from RhoGEF-PH through the insertion of SH3 independently, while SH3-RhoGEF of proteins in fruit fly might have evolved from SH3-RhoGEF-PH by the degeneration of PH domain.
