Study on the therapeutic effect of combined use of ant i-silicosis drugs on early experimental silicosis of rats
10.3760/cma.j.issn.1001-9391.2001.01.003
- VernacularTitle:联合用药治疗大鼠早期矽肺的疗效观察
- Author:
Changqi ZOU
1
;
Qingcheng DU
;
Peihong ZHOU
Author Information
1. Institute of Occupational Medicinez,Chinese Ac ademy of Preventive Medicine
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2001;19(1):7-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of combined use of anti-silicosis drugs on early silicosis of rats. Methods Male Wistar rats were exposed to lower dose(20 mg/rat) of quartz by intr atracheal injection.In the early stage of silicosis,the experimental rats were t reated with 4 single drugs,i.e. poly-2-vinyl pyridine-nitrogen oxide(PVNO),te trandrine(TD),quinolyl-piperazine hydroxyl phosphate(QOHP),aluminium citrate(AL C ) and 3 combined drugs i.e. PVNO+TD,TD+QOHP,ALC+TD for 2 and 5 months respective ly. Results The wet and dry weight and collagen content of w hole rat lung in all of treated groups were obviously lower than that of quartz control groups(P<0.05 or P<0.01),but there were no significant d ifferences between the groups of single treatment and the groups of combined tre atment (P>0.05) except some items on 150 d.Evalutaion by RSR showed th at combined use of ALC+QOHP and TD+QOHP for both 60 d and 150 d were much more e fficient than single use of drugs.Treatment with PVNO+TD for 150 d was also bett er than single use.Pathological examination showed that silicotic lesions of rat lung were much lighter in treated groups than that of quartz groups,and also li ghter 1/2～1 grade in combined use groups as compared to single use groups. Conclusion The therapeutic effects of combined use of anti-s ilicosis drugs on early silicosis were better than those of single drugs.
