Hierarchical evolution of bone biomimicry and osteo-coagulo-immunomodulation induced by the size of biological hydroxyapatite
10.7518/hxkq.2024.2024315
- VernacularTitle:生物源性钙磷灰石尺寸引发的骨仿生层级演变及其骨凝血免疫效应
- Author:
Jieyun XU
1
;
Yuan ZHAO
;
Haozhou LIU
;
Jingyuan YIN
;
Zetao CHEN
Author Information
1. 中山大学附属口腔医院,广东省口腔医学重点实验室,广州 510055
- Keywords:
biological hydroxyapatite;
biomimetic hierarchical evolution;
osteo-coagulo-immunomodula-tion;
material size effect
- From:
West China Journal of Stomatology
2024;42(6):706-715
- CountryChina
- Language:Chinese
-
Abstract:
Biological hydroxyapatite(BHA)is widely used in the treatment of clinical bone defects due to its good biocompatibility and osteoconductivity.The clinical application of mateiral size is based on the principle of bone defect area adaptation,which contributes to diversity of BHA sizes.However,different sizes correspond to different hierarchi-cal levels of bone biomimicry.As the size changes,the bone biomimicry hierarchy evolves accordingly and influences the process of bone repair and regeneration through osteo-coagulo-immunomodulation,leading to unstable bone graft outcomes.Therefore,this paper reviews the size effect of clinical BHA,analyzes the multilevel structure of natural bone,proposes the evolution of bone biomimetic hierarchy triggered by the size of BHA,and further analyzes the size-media-ted osteo-coagulo-immunomodulation.Based on the hierarchical levels of bone and its osteo-coagulo-immunomodula-tion effect,we provide a new understanding of the biolog-ical principle of the size effect of biomaterials and a theo-retical basis for the basic research and clinical application of different size BHA materials.
