Potential correlation between chronic periodontitis and Parkinson's disease
10.7518/hxkq.2024.2024010
- VernacularTitle:慢性牙周炎与帕金森病之间潜在相关性的初探
- Author:
Rongxia YANG
1
;
Yingrui ZONG
;
Chen ZHANG
Author Information
1. 郑州大学第一附属医院口腔综合科,郑州 450052
- Keywords:
chronic periodontitis;
Parkinson's dis-ease;
hub gene;
transcription factor;
Mendelian ran-domization
- From:
West China Journal of Stomatology
2024;42(4):521-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aims to investigate possible hub genes,associated pathways,and transcription fac-tors between chronic periodontitis(CP)and Parkinson's disease(PD).Methods Gene expression profiles of CP(GSE16134,GSE23586,and GSE10334)and PD(GSE20141 and GSE49036)were downloaded from the gene expres-sion omnibus(GEO)database for differential expression analysis and functional clustering analysis.The protein-protein interaction(PPI)network was constructed,and hub genes were screened by four topological analysis algorithms and modular segmentation.Functional clustering analysis was performed.The hub genes were validated by external datasets of CP and PD,and causal relation was further assessed by Mendelian randomization(MR).Results After merging the data,1 211 differentially expressed genes(DEGs)were screened in the CP datasets;of which,551 were upregulated and 660 were downregulated.A total of 2 407 DEGs were screened in the PD dataset,of which,1 438 were upregulated and 969 were downregulated.The PPI network included 145 nodes and 126 edges.Four hub genes(FCGR3B,PRF1,IL18,and CD33)and three transcription factors(HSF1,HSF2,and HSF4)were finally screened.The relevant pathway was pre-dominantly natural killer(NK)cell-mediated toxic effects.The MR results suggest a possible positive causal relationship between CP and the risk of developing PD.Conclusion This study indicated the probably shared pathophysiology and possible causal relationship between CP and PD and may offer novel concepts and therapeutic targets for future mecha-nistic investigations.
