Clinical Study of the Effect of Aprotinin for Hemostasis in Open Heart Surgery.
- Author:
Sung Woon JUNG
1
;
Jong Won KIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Pusan National University.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Aprotinin;
Hemostasis
- MeSH:
Anesthesia;
Aprotinin*;
Busan;
Heart Valves;
Heart*;
Hemostasis*;
Humans;
Postoperative Hemorrhage;
Skin;
Thoracic Surgery*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
1999;32(4):364-367
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The efficacy of the hemostasis of prophylactic aprotinin after cardiac valve replacement was evaluated from January 1994 to December 1996 at Pusan National University Hospital. MATERIAL AND METHOD: In a randomized study, 20 patients received aprotinin(2x106 KIU as a loading dose for 30 minutes after anesthesia, 1x106 KIU for priming and 5x105 KIU/hr as a maintenance dose from the completion of loading dose till skin closure) and another 20 untreated patients served as controls. RESULT: Aprotinin produced a significant reduction in postoperative blood loss compared with controls and significantly decreased total exposure to allogenic blood products compared with the control group(p<0.05). CONCLUSION: We conclude that aprotinin effectively reduces postoperative blood loss and trasfusion in patient undergoing cardiac valve replacement.
