Gluteal tendinitis and primary coxarthrosis may lead to iliotibial band syndrome:a Mendelian randomization study
10.12122/j.issn.1673-4254.2024.09.23
- VernacularTitle:臀肌腱炎、原发性髋关节病可能导致髂胫束综合征—一项孟德尔随机化研究
- Author:
Chen YAO
1
;
Wenjia LI
;
Ruiming PANG
;
Jihong ZHOU
Author Information
1. 广州中医药大学附属宝安中医院骨伤科一区,广东 深圳 518000
- Keywords:
gluteal tendonitis;
primary coxarthrosis;
iliotibial band syndrome;
Mendelian randomization
- From:
Journal of Southern Medical University
2024;44(9):1821-1830
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the causal relationship of gluteal tendinitis and primary coxarthrosis with the occurrence of iliotibial band syndrome using Mendelian randomization.Methods The GWAS data of gluteal tendinitis,primary coxarthrosis and iliotibial band syndrome were screened for high correlation single-nucleotide polymorphisms(SNPs).Mendelian randomization analysis was performed using random-effects inverse variance weighting(IVW),MR-Egger regression,and weighted median method to determine whether gluteal tendinitis and primary coxarthrosis were causally related with iliotibial band syndrome.Heterogeneity test,multiple validity test and sensitivity analysis,and clinical data analysis were used to verify the reliability of the results.Results Both gluteal tendinitis[IVW:OR(95%CI)=1.32(1.03-1.68),P=0.026]and primary coxarthrosis[IVW:OR(95%CI)=1.40(1.06-1.84),P=0.017]was positively correlated with iliotibial band syndrome.Conclusion Gluteal tendinitis and primary coxarthrosis may increase the risk of iliotibial band syndrome.
