Clinical efficacy of early micro-porous surgery in treatment of patients with encephaledema after small-and moderate-volume basal ganglia hemorrhage and its influence on serum inflammatory factors
10.7619/jcmp.201701019
- VernacularTitle:早期微孔手术治疗中小量基底节脑出血后脑水肿的疗效及对血清炎性因子的影响
- Author:
Hui LI
1
;
Xiaosen DAI
;
Dewen HOU
;
Jinkun WANG
Author Information
1. 四川省遂宁市中医院脑病中心神经外科
- Keywords:
micro-porous surgery;
encephaledema after small-and moderate-volume basal ganglia hemorrhage;
clinical efficacy;
serum inflammatory factors;
neurological function
- From:
Journal of Clinical Medicine in Practice
2017;21(1):65-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of early micro-porous surgery in the treatment of patients with encephaledema after small-and moderate-volume basal ganglia hemorrhage and its influence on serum inflammatory factors.Methods A total of 104 patients with small-and moderate-volume basal ganglia hemorrhage were randomly divided into control group and observation group,52 cases in each group.Control group was treated with conventional treatment,while observation group was treated with early micro-porous surgery.The volume of encephaledema and clearance time of hematoma 3 d and 14 d after treatment were observed in both groups.The levels of serum interleukin-6 (IL-6),IL-13 and tumor necrosis factors-α (TNF-o) were detected before treatment and 3 d after treatment in both groups.National Institutes of Health Stroke Scale (NIHSS) and Activities of Daily Life Function Assessment Scale Barthel index (BI) were used before and 3 weeks after treatment to evaluate patients' neurological function.Results The 3 d and 14 d after treatment,observation group was significantly smaller in volume of encephaledema (P ＜ 0.05) and shorter in clearance time of hematoma (P ＜0.01) when compared with control group.Three days after treatment,levels of serum IL-6,IL-1 β and TNF-α decreased significantly in both groups,which decreased more significantly in observation group than in control group (P ＜0.05 or P ＜0.01).Three weeks after treatment,NIHSS score decreased significantly while BI increased significantly in both groups,which improved more significantly in observation group than in control group (P ＜ 0.05).Conclusion Early micro-porous surgery can significantly relieve the severity of encephaledema after intracerebral hemorrhage,and has greater advantages in recovering patients' neurological function.
