Potential mechanism of ginseng in the treatment of periodontitis based on network pharmacology and molecular docking
10.7518/hxkq.2024.2023285
- VernacularTitle:基于网络药理学和分子对接技术探讨人参对牙周炎的潜在治疗机制
- Author:
Jinmeng SUN
1
;
Ying ZHANG
;
Zejun ZHENG
;
Xiaoling DING
;
Minmin SUN
;
Gang DING
Author Information
1. 山东第二医科大学口腔医学院,潍坊 261053
- Keywords:
ginseng;
periodontitis;
network pharmacology;
molecular docking;
mechanism
- From:
West China Journal of Stomatology
2024;42(2):181-191
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of ginseng in the treatment of periodontitis based on network phar-macology and molecular docking technology.Methods Potential targets of ginseng and periodontitis were obtained through various databases.The intersection targets of ginseng and periodontitis were obtained by using VENNY,the pro-tein-protein interaction network relationship diagram was formed on the STRING platform,the core target diagram was formed by Cytoscape software,and the ginseng-active ingredient-target network diagram was constructed.The selected targets were screened for gene ontology(GO)and Kyoto encyclopedia of genes and genomes(KEGG)pathway en-richment analysis.The core targets of ginseng's active in-gredients in treating periodontitis were analyzed by mo-lecular docking technique.Results The 22 ginseng's active ingredients,591 potential targets of ginseng's ac-tive ingredients,2 249 periodontitis gene targets,and 145 ginseng-periodontitis intersection targets were analyzed.Ginseng had strong binding activity on core targets such as vas-cular endothelial growth factor A and epidermal growth factor receptor,as well as hypoxia induced-factor 1(HIF-1)sig-naling pathway and phosphatidylinositol 3-kinase-protein kinase B(PI3K-Akt)signaling pathway.Conclusion Gin-seng and its active components can regulate several signaling pathways such as HIF-1 and PI3K-Akt,thereby indicating that ginseng may play a role in treating periodontitis through multiple pathways.
