Causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus:a two-sample bidirectional Mendelian randomization study
10.12122/j.issn.1673-4254.2024.08.21
- VernacularTitle:睡眠性状与特发性正常压力脑积水的因果关联:一项两样本双向孟德尔随机化研究
- Author:
Weitao ZHONG
1
;
Weisong LI
;
Zelin LI
;
Qiang WANG
;
Wangming ZHANG
Author Information
1. 南方医科大学珠江医院神经外科中心小儿神经外科//广东省脑功能修复与再生重点实验室//国家临床重点专科//教育部工程技术研究中心,广东 广州 510282
- Keywords:
Mendelian randomization;
sleep phenotype;
idiopathic normal pressure hydrocephalus;
day nap
- From:
Journal of Southern Medical University
2024;44(8):1612-1619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between sleep phenotype and idiopathic normal pressure hydrocephalus(iNPH)using two-sample bidirectional Mendelian randomization.Methods The exposure data including 8 sleep phenotypes used in this study were obtained from GWAS catalog,FinnGenR10 and MRCIEU GWAS.The outcome data for idiopathic normal-pressure hydrocephalus were obtained from FinnGen R10.We used the inverse-variance weighted(IVW)method to perform the principal analyses.Cochrane Q-statistics test was used to assess the heterogeneity and MR Egger-intercept test performed to evaluate the pleiotropy for sensitivity analyses.Results IVW result showed that frequent daytime nap was associated with higher odds of iNPH(OR=3.3393,95 CI%:1.0646-10.4742,P=0.0270).Cochrane Q-statistics test and MR Egger-intercept test showed that the MR analysis had no pleiotropy or heterogeneity(P>0.05).The external validation reproduced this result(OR=2.5660,95 CI%:1.1680-5.6373,P=0.0189;OR=4.0424,95 CI%:1.5709-10.4024,P=0.0038).Reverse Mendelian randomization suggested that iNPH did not have significant impact on sleep phenotype.Conclusion The frequency of daytime naps is causally associated with iNPH,and reducing the frequency of weekly daytime naps can reduce the risk of iNPH in the elderly population.
