Causal relationship between gut microbiota and pigmented villonodular synovitis:a Mendelian randomization analysis
10.12122/j.issn.1673-4254.2024.07.20
- VernacularTitle:肠道菌群与色素沉着绒毛结节性滑膜炎之间的因果关系:基于孟德尔随机化分析
- Author:
Jiajin LIU
1
,
2
;
Changhong MIAO
;
Jiankang XU
;
Weijie YU
;
Jixin CHEN
;
Haozhi TANG
;
Aifeng LIU
Author Information
1. 天津中医药大学第一附属医院,天津 300381
2. 国家中医针灸临床医学研究中心,天津 300381
- Keywords:
gut microbiota;
pigmented villonodular synovitis;
Mendelian randomization;
causality
- From:
Journal of Southern Medical University
2024;44(7):1397-1406
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationship between gut microbiota and pigmented villonodular synovitis using Mendelian randomization analysis.Methods We conducted a two-sample Mendelian randomization analysis to investigate the causal relationship between 211 gut microbiome taxa and pigmented villonodular synovitis based on GWAS summary data,with inverse variance weighted(IVW)analysis as the primary result and the other methods as supplementary analyses.The reliability of the results was tested using Cochran's Q test,MR-Egger regression,MR-PRESSO method and conditional Mendelian randomization analysis(cML-MA).Results The increased abundance of Barnesiella(OR=3.12,95%CI:1.15-8.41,P=0.025)and Rumatococcaceae UCG010(OR=4.03,95%CI:1.19-13.68,P=0.025)may increase the risk of pigmented villous nodular synovitis,and elevated abundance of Lachnospiraceae(OR=0.33,95%CI:0.12-0.91,P=0.032),Alistipes(OR=0.16,95%CI:0.05-0.53,P=0.003),Blautia(OR=0.20,95%CI:0.06-0.61,P=0.005),and Lachnospiraceae FCS020 group(OR=0.38,95%CI:0.15-0.94,P=0.036)and Ruminococcaceae UCG014(OR=0.36,95%CI:0.14-0.94,P=0.037)were all associated with a reduced risk of pigmented villonodular synovitis,which were supported by the results of sensitivity analyses.Reverse Mendelian randomization analysis did not reveal any inverse causal association.Conclusion Increased abundance of specific intestinal microorganisms is associated with increased or decreased risks of developing hyperpigmented villonodular synovitis,and gut microbiota plays an important role in the pathogenesis of this disease.
