Application of different doses of dexmedetomidine and midazolam in dental implant surgery
10.7518/hxkq.2015.02.009
- VernacularTitle:不同剂量的右美托咪啶和咪唑安定在口腔种植手术中的镇静效果
- Author:
Peng LI
1
;
Juan LIAO
;
Mengchang YANG
;
Jun GUO
Author Information
1. 四川省医学科学院 四川省人民医院麻醉科
- Keywords:
dexmedetomidine;
midazolam;
anesthesia;
sedation;
dental implant
- From:
West China Journal of Stomatology
2015;(2):153-157
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo?compare?the?sedative?effects?of?different?doses?of?dexmedetomidine?(DEX)?and?midazolam?(MDZ)?in?dental?implant?surgery.?Methods???Sixty?patients?undergoing?dental?implantation?were?selected?and?divided?randomly?into?six?groups?(10?in?each?group).?In?group?1?(G1),?a?highdose?of?MDZ?alone?was?administered?intravenously.?In?group?2?(G2),?a?relatively?low?dose?of?MDZ?and?DEX?was?administered?intravenously.?In?group?3?(G3),?a?highdose?of?MDZ?and?DEX?was?ad-ministered?intravenously.?In?group?4?(G4),?a?lowdose?of?MDZ?and?a?highdose?of?DEX?were?administered.?In?group?5(G5),?a?highdose?of?MDZ?and?a?low?dose?of?DEX?were?administered.?In?group?6?(G6),?a?highdose?of?DEX?alone?was?administered?intravenously.?Blood?pressure?(BP),?heart?rate?(HR),?and?arterial?oxygen?saturation?values?were?measured.?Sedation?was?as-sessed?by?determining?the?Ramsay?sedation?scores(RSS)?during?infiltration?anesthesia?(T1),?incision?(T2),?cutting?(T3),?and?suturing?(T4).?Before?discharging?from?the?hospital,?patients?were?asked?if?they?remembered?the?T1?to?T4?procedures.?The?visual?analogue?scale?(VAS)?and?the?degree?of?patient?satisfaction?were?assessed?at?the?same?time.?Results???In?T1?to?T4,?the?systolic?blood?pressure?(SBP)?in?G3?was?the?lowest?and?was?significantly?different?from?that?in?G1?and?G2?(P<0.05).?In?G1,?the?SBP?was?higher?than?that?in?G6?at?the?T3?and?T4?points?(P<0.05).?HR?was?below?the?preoperative?(P<0.05)?in?the?G3?only.?RSS?was?the?lowest?in?G1?during?the?whole?procedure.?In?G2,?most?patients?obtained?scores?of?2–3.?In?G3,?sedation?was?deeper,?had?more?cases?of?up?to?5.?In?G4,?most?patients?obtained?scores?of?3–4.?In?G5,?some?patients?had?a?score?of?up?to?5.?The?RSS?in?G6?was?lower?than?that?in?G3?and?G4?or?G5?in?T1?to?T2,?closer?to?G4?in?T2.?An?evaluation?of?the?VAS?and?the?degree?of?patient?satisfaction?did?not?show?any?differences?among?the?groups.?Conclusion???The?combination?of?DEX?and?MDZ?is?superior?to?a?single?intravenous?injection.?Low-dose?MDZ?combined?with?high-dose?DEX?achieved?the?highest?quality?of?sedation?in?this?study.
