Expression and clinical significance of nuclear factor κB/B cell lymphoma-2 signal pathway and glycogen synthase kinase 3β in oral squamous cell carcinoma
- VernacularTitle:核因子κB/B细胞淋巴瘤2信号通路与糖原合成激酶3β在口腔鳞状细胞癌中的表达及临床意义
- Author:
Yuhua ZHAN
1
;
Han CUI
;
Jiyuan LIU
;
Wei ZHOU
;
Lin QUE
;
Xiufa TANG
Author Information
- Keywords: glycogen synthase kinase 3β; nuclear factor κB; B cell lymphoma-2; oral squamous cell carcinoma
- From: West China Journal of Stomatology 2015;(1):11-15
- CountryChina
- Language:Chinese
- Abstract: Objective This study aims to examine the expression of nuclear factor κB (NF-κB)/B cell lymphoma-2 (Bcl-2) signal pathway and glycogen synthase kinase 3β (GSK-3β) in oral squamous cell carcinoma (OSCC) and provide references for the early diagnosis and prognosis evaluation of OSCC. Methods A total of 55 cases of OSCC and 10 cases of paracan-cerous mucosa were examined in this study. Their expressions of GSK-3β, NF-κB and Bcl-2 were detected using the SP me-thod immunohistochemistry. The correlation between their expression in OSCC and the clinical and pathological peculiarity of OSCC was analyzed. Results The positive expression of GSK-3β, NF-κB, and Bcl-2 in OSCC were significantly higher than that in paracancerous mucosa (P<0.01). The expression of GSK-3β, NF-κB, and Bcl-2 had no obvious relationship with patient’s age, sex, and clinical stages of the disease (P>0.05). The expression of Bcl-2 was significantly correlated with the degree of tumor differentiation (P<0.05), whereas the expression of GSK-3β and NF-κB in OSCC had no obvious relation-ship with the degree of tumor differentiation (P>0.05). Strong positive correlations were observed among the expressions of GSK-3β, NF-κB, and Bcl-2 (P<0.05). Conclusion The positive expression of GSK-3β, NF-κB, and Bcl-2 in OSCC are sig-nificantly higher than that in paracancerous mucosa. Detecting GSK-3β, NF-κB, and Bcl-2 in OSCC may have implications in the early diagnosis and prognosis evaluation of OSCC.
