Expression and clinical significance of serine-threonine kinase/mammalian target of rapamycin/p70 S6K signal path-way in oral squamous cell carcinoma
- VernacularTitle:丝/苏氨酸蛋白激酶/哺乳动物雷帕霉素靶蛋白/p70S6K信号通路在口腔鳞癌中的表达及临床意义
- Author:
Jieru JIA
1
;
Shuang LIANG
;
Jiyuan LIU
;
Jun ZHAO
;
Xiufa TANG
Author Information
- Keywords: serine-threonine kinase; mammalian target of rapamycin; p70 S6K; oral squamous cell carcinoma; im-munohistochemistry
- From: West China Journal of Stomatology 2014;(5):504-508
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the expressions of serine-threonine kinase (Akt)/ mammalian target of rapamycin (mTOR)/p70 S6K in oral squamous cell carcinoma (OSCC) and provide references for early diagnosis and prognosis evalua-tion of OSCC. Methods A total of 51 cases of OSCC, 10 cases of paracancerous mucosa, and 10 cases of normal oral mucosa were collected. The expressions of Akt/mTOR/p70 S6K in these cases were detected using the SP method of immunohisto-chemistry. The correlation between their expressions in OSCC was also analyzed. Results The positive expressions of p-Akt, p-mTOR, and p70 S6K in OSCC were significantly higher than those in normal oral mucosa and paracancerous mucosa. The expressions of p-Akt, p-mTOR, and p70 S6K in OSCC were not correlated with age, gender, and clinical stage; by comparison, these expressions were correlated with lymph node metastasis and pathological grade. Strong positive correlations were also observed between the expressions of p-Akt, p-mTOR, and p70 S6K in OSCC. Conclusion Akt/mTOR/p70 S6K signaling molecules exhibit active expressions in OSCC and may be implicated in the occurrence and development of OSCC.
