Randomized controlled trial of nurse intervention of urea-based cream on sorafenib-associated hand-foot skin reactions of patients
- VernacularTitle:尿素乳膏护理干预索拉非尼相关手足皮肤反应随机对照研究
- Author:
Linjing AN
1
;
Xin ZHANG
;
Lina ZHANG
;
Yinyin LI
;
Yinying LU
;
Yongping YANG
Author Information
- Keywords: nurse intervention; UBC; sorafinib; hand-foot skin reaction; advanced hepatocellular carcinoma
- From: Journal of Clinical Medicine in Practice 2014;(22):45-47,54
- CountryChina
- Language:Chinese
- Abstract: ABSTRACT:Objective To assess the effect of nurse intervention of urea-based cream (UBC)on sorafenib-induced hand-foot skin reaction (HFSR)in patients with advanced hepato-cellular carcinoma(HCC).Methods 202 advanced HCC patients were randomly divided into 2 groups.101 patients in the urea-based cream group were applied with 10% UBC three times dai-ly and best nursing while 110 patients in the control group were applied basic nursing alone.The treatment lasted for 12 weeks.HFSR was assessed every 2 weeks.Once HFSR occurred,patients were allowed any cream,including UBC.Results After the nursing,the incident rate of HFSR and incidence of grade ≥2 HFSR in the UBC group were lower that than in the BNC group.The Median time to first occurrence of HFSR was 1.63 times of UBC group.UBC did not affect the adjustment of sorafenib dose,response or disease control.Conclusion UBC nurse intervention of advanced HCC patients could reduce HFSR rate,extend the time of first occurrence of HFSR and improve the quality of life of patients.
