Postoperative changes of Th17/Treg balance in patients with intracranial aneurysm rupture
10.3969/j.issn.1673-4254.2017.04.22
- VernacularTitle:颅内动脉瘤破裂患者手术前后Th17/Treg的变化
- Author:
Zai LIANG
1
;
Hongjian JIAN
;
Qianyi LIN
;
Saihua LUO
;
Xiaopeng ZHANG
Author Information
1. 广东医科大学附属廉江医院廉江市人民医院神经外科
- Keywords:
aneurysm;
Th17 cells;
regulatory T cells
- From:
Journal of Southern Medical University
2017;37(4):546-550
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the dynamic changes of Th17/Treg balance in patients following surgical intervention for intracranial aneurysm rupture. Methods The percentage of Th cells and the intracellular IL-17 level, Treg cell percentage and transforming growth factor-β1 (TGF-β1) levels were examined in 73 patients with rupture of aneurysms before and at 24 h, 72 h and 1 week after operation, with 62 patients with unruptured aneurysms and 65 healthy volunteers as the control. The correlations among the immune cells, cytokines and clinical characteristics of the patients (NIHSS, ADL and hospitalization stay) were analyzed. Results Th17 percentage and intracellular IL-17 levels were significantly higher in the patients with ruptured and unruptured aneurysms than in the healthy volunteers, and were significantly higher in patients with ruptured aneurysms than in those with unruptured aneurysms. Treg cell percentage and TGF-β1 level were significantly lower in patients with aneurysms than in the healthy volunteers, and were lower in patients with ruptured aneurysms than in those with uruptured aneurysms (P<0.05). Patients with intracranial aneurysm rupture showed significantly increased Th17 cell percentage and IL-17 level but significantly lowered Treg cell percentage and TGF-β1 at 24 h following the surgery (P<0.05);these changes were reversed significantly at 72 h and 1 week after the surgery. Th17 cell percentage and IL-17 level were positively correlated with NIHSS and the length of postoperative hospital stay but inversely correlated with ADL; Treg cell percentage and TGF-β1 were inversely correlated with NIHSS and hospital stay but positively with ADL (P<0.05). Conclusion In patients with intracranial aneurysms, the systemic immune inflammatory response is highlighted by excessive Th17 cells and insufficient Treg cells, which are closely related with the outcomes of the patients following surgical intervention. Evaluation of Th17/Treg balance and the cytokine levels can help to assess the prognosis of patients with aneurysm rupture.
