Experimental study on hepatitis B-virus X gene expression in adenoid cystic carcinoma
10.7518/hxkq.2014.04.003
- VernacularTitle:乙型肝炎病毒X基因在涎腺腺样囊性癌中表达的实验研究
- Author:
Ling XIE
1
;
Weihong WANG
;
Biao XU
;
Yu LIU
Author Information
1. 新津县人民医院口腔科
- Keywords:
adenoid cystic carcinoma;
hepatitis B virus;
hepatitis B-virus X gene
- From:
West China Journal of Stomatology
2014;(4):328-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of hepatitis B-virus X gene (HBX) in adenoid cystic carcinoma (ACC) and determine its clinical significance. Methods Between June 2008 and October 2012, in-hospital patients with salivary gland tumors who were treated at the Department of Oral and Maxillofacial Surgery, Affiliated Stomatology Hospital of Kunming Medical University, were enrolled to this study. HBeAb-positive patients were defined as those exposed to hepatitis B virus (HBV) or harboring persistent HBV infection regardless of being HBeAg positive or negative. According to the pathological results, all patients were divided into ACC group and control group. Immunohistochemical staining and polymerase chain reaction (PCR) were used to detect HBX expression in ACC group and control group. Results HBX expression was mostly detected in the cytoplasm of ACC cells. Minimal HBX expression was detected in the nucleus. HBX expression was significantly higher in ACC than in Warthin’s tumor. A significant difference was observed between the two groups. Conclusion HBX is expressed in ACC and may be associated with the development of ACC. HBX might serve important functions in the carcinogenesis and development of ACC.
