Effects of Porphyromonas gingivalis infection on intercellular adhesion molecule-1 expression in rat vascular smooth muscle cells
10.7518/hxkq.2014.02.002
- VernacularTitle:牙龈卟啉单胞菌感染对大鼠血管平滑肌细胞细胞间黏附分子-1表达的影响
- Author:
Jiayin DAI
1
;
Jiang LIN
;
Liangjia BI
;
Lining JIAO
;
Qiang WANG
Author Information
1. 哈尔滨医科大学附属第四医院口腔科
- Keywords:
Porphyromonas gingivalis;
vascular smooth muscle cells;
atherosclerosis;
intercellular adhesion molecule-1
- From:
West China Journal of Stomatology
2014;(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Porphyromonas gingivalis (P. gingivalis) ATCC 33277 infection on ex-pression of intercellular adhesion molecule-1 (ICAM-1) in rat vascular smooth muscle cells(VSMC). Methods An infection model of rat VSMC invaded by P. gingivalis was established in vitro. The mRNA of ICAM-1 was measured through reverse transcription-polymerase chain reaction (RT-PCR). Results Compared with the control group, an apparent and statistically significant increase in expression of ICAM-1 mRNA was observed after 8, 16, and 24 h in P. gingivals-infected rat VSMC (P<0.05). The expression reached its peak at 16 h. Statistically significant differences were observed in the 8 h group and in the other two experimental groups (P<0.05). Conclusion Infection of P. gingivals in rat VSMC can cause increased expres-sion of ICAM-1, which may have an important function in the progression of atherosclerosis.
