Anesthetic effects of repeated dosing with propofol and vitamin C in mice
10.3969/j.issn.1673-4254.2015.12.07
- VernacularTitle:连续多次应用丙泊酚复合维生素C对小鼠麻醉效应的影响
- Author:
Mengzhuo GUO
1
;
Weiguang LI
;
Xu LIU
;
Zeguo FENG
;
Chenggang ZHANG
;
Fangyong WU
;
Lianjun HUANG
;
Yingqun YU
Author Information
1. 解放军总医院麻醉手术中心
- Keywords:
propofol;
vitamin C;
anesthesia;
loss of righting reflex
- From:
Journal of Southern Medical University
2015;(12):1701-1704
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the anesthetic effects of repeated administration of propofol combined with vitamin C in mice. Methods Forty mice were subjected to daily intraperitoneal injections of 80 mg/kg propofol (P80 group), 70 mg/kg propofol and 50 mg/kg vitamin C (P70+Vc50 group), 55 mg/kg propofol and 100 mg/kg vitamin C (P55+Vc100 group), or 50 mg/kg propofol and 200 mg/kg vitamin C (P50+Vc200 group) for 6 consecutive days, and the anesthesia induction time and anesthesia duration were recorded. Results Compared with the P80 group, the mice in P55 + Vc100 group and P50 + Vc200 group showed significantly shorter anesthesia duration on the first 3 days (P<0.05). In all the groups, anesthesia duration was significantly shortened in the following days compared with that on day 1 (P<0.01);anesthesia duration was shorter on day 3 than on day 2 in P50+Vc200 group (P<0.01), and was shorter on days 4, 5, and 6 than on day 2 in all the groups (P<0.01). In all the groups, the rate of loss of righting reflex (LORR) decreased gradually with time in a similar pattern. Conclusions Vitamin C can reduce the dose of propofol without obviously affecting the anesthetic effect to reduce the incidence of drug tolerance and potential dose-related side effects of propofol.
