Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in Chinese Han population in Hainan Province
- VernacularTitle:海南汉族PLAG1基因rs6474051多态性与腮腺良性肿瘤的关联性
- Author:
Xiang HUANG
1
;
Xunding QIU
;
Minglei SUN
;
Shengteng HE
Author Information
1. 海南省农垦三亚医院口腔科
- Keywords:
benign parotid tumor;
pleomorphic adenoma gene 1;
single nucleotide polymorphism;
rs6474051
- From:
Journal of Southern Medical University
2015;(9):1360-1361,1365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province. Methods Sixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing. Results Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30%in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05). Conclusion Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.
