Expressions of CD133, E-cadherin, and Snail in epithelial ovarian cancer and their clinico-pathologic and prognostic implications
- VernacularTitle:上皮性卵巢癌中CD133与EMT相关因子表达的关系
- Author:
Lan YU
1
;
Lei ZHOU
;
Shiwu WU
;
Wenqing SONG
;
Zenong CHENG
;
Bingqin GUO
Author Information
1. 蚌埠医学院第一附属医院临床病理科//蚌埠医学院病理学教研室//安徽省感染与免疫重点实验室
- Keywords:
epithelial ovarian cancer;
CD133;
snail;
E-cadherin;
prognosis
- From:
Journal of Southern Medical University
2015;(9):1297-1302
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore expressions of CD133, E-cadherin and Snail in hu?man epithelial ovarian cancer (EOC) and elucidate their relationship with the clinicopathologic features and prognosis of the patients. Methods The expression of CD133, E-cadherin and Snail were detected by immunohistochemical staining in 150 specimens of EOC and 50 specimens of benign ovarian epithelial tumor tissues. Results The positivity rates of CD133, E-cadherin and Snail protein in EOC were 58.7%, 60.7%and 32.7%, respectively, significantly different from the rates in benign epithelial tumor tissues (10%, 8.0%, and 70%, respectively; P<0.05). The expressions of CD133, E-cadherin and Snail in EOC were significantly correlated with abdominal organ and lymphnode metastases and FIGO stage (P<0.01). E-cadherin expression was inversely correlated with Snail and CD133 expression (r=-0.545 and-0.570, P<0.01), and the latter two were positively correlated (r=0.599, P<0.01). Overexpressions of CD133 and Snail and a decreased expression of E-cadherin were all related to a poor prognosis of the patients (P<0.05). FIGO stage and expressions of CD133, E-cadherin and Snail were all independent prognostic factors of EOC (P<0.05). Conclusion The expressions of CD133, E-cadherin and Snail are related to lymph node metastasis, clinical stage, and prognosis of EOC. Combined detection of these indexes provides important evidence for predicting the progression and prognosis of EOC.
