Copeptin and ischemia modified albumin expression and significance of early in acute paraquat poisoning
- VernacularTitle:和肽素及缺血修饰白蛋白在急性百草枯中毒早期的表达及意义
- Author:
Jing LI
1
;
Rongxia WANG
;
Jiaqi HE
;
Jianjun ZHANG
;
Baoyue ZHU
;
Wei LI
;
Weizhan WANG
Author Information
- Keywords: Acute paraquat poisoning; Myocardial injury; copeptin; ischemia modified albumin
- From: Journal of Clinical Medicine in Practice 2014;(16):40-43
- CountryChina
- Language:Chinese
- Abstract: Objective To make a discussion on patients with acute paraquat poisoning (APP) early copeptin and ischemia modified albumin expression and its clinical significance.Methods 93 APP patients were selected as the poisoning group,the hospital clinical death as the endpoint,di-vided into survival group (48 cases)and death group(45 cases).All patients after admission in 2 h, 24 h in blood samples were 3 mL,detection of myocardial enzymes,cTnI,IMA,Copeptin.Re-sults Compared the death group and survival group,Death group of oral dose than the survival group had significant difference.While the rescue time,for the first timeof hemoperfusion and times with no difference.2h after admission Copeptin,IMA levels elevated,the death group and survival group have significant difference.24 h Copeptin,cTnI,CK,CK-MB in death group was significantly higher than the survival group(P <0.05).IMA comparison between two groups was no significance.Patients with APP oral dose was positively correlated with Copeptin;and IMA (ACB value)was negative correlation.More oral dose,Copeptin,IMA increased significantly. Copeptin was negatively correlated with IMA levels. Regression analysis, suggesting that Copeptin,IMA,cTnI,CK,CK-MB in patients with oral dose showed a linear relationship.Con-clusion There is an important significance in early diagnosis of APP myocardial injury in the early detection of IMA and Copeptin,a correlation between concentration and prognosis,which is more severe illness,its content is higher,the worse the prognosis.It has an important clinical value for evaluating prognosis.
