Clinical value of combined detection of plasma vWF and platelet parameters in patients with type 2 diabetes mellitus complicatedwith cerebral infarction
10.7619/jcmp.201416006
- VernacularTitle:2型糖尿病并发脑梗死患者联合检测血浆 vWF 水平及血小板参数的临床价值
- Author:
Xiaohua JU
1
;
Baoming XIE
;
Jinbiao ZHANG
Author Information
1. 山东省威海市立医院 神经内科
- Keywords:
type 2 diabetes mellitus;
cerebral infraction;
von Willebrand factor;
glcated hemoglobin;
platelet distribution width;
platelet volume
- From:
Journal of Clinical Medicine in Practice
2014;(16):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of plasma vWF and platelet pa-rameters in patients with type 2 diabetes mellitus (T2DM)complicated with cerebral infraction. Methods A total of 32 patients with T2DM complicated with cerebral infraction from December 2011 to October 2013 and another 32 patients with single T2DM were selected as combination group and T2DM group,while another 30 healthy people served as control group.Glycated hemoglobin (HbA1c)level,von Willebrand factor (vWF)level and platelet parameters were detected in 3 groups to observe their differences and the relationship between HbA1c level and vWF level and platelet parameters were analyzed.Results HbA1c and vWF levels decreased gradually in combina-tion and T2DM groups than that in control group,and the differences were significant (P <0.01). There was no significant difference in platelet count (PLT)among 3 groups (P >0.05).However, platelet distribution width (PDW)and mean platelet volume (MPV)decreased evidently and gradu-ally in 3 groups (P <0.01).Additionally,HbA1c level was positive associated with vWF,PMV and PDW (P <0.01).Conclusion Level of vWF increases significantly in patients with T2DM complicated with cerebral infarction,whose detection combined with platelet parametes can provide references for the early diagnosis and treatment.
